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High-throughput sequencing and dual-luciferase reporter gene analysis show that exercise induces an increase of skeletal muscle exosomes and exosomal miR-484 could enter the brain through blood circulation to inhibit the expression of ACSL4 and thus inhibit ferroptosis of nerve cells

10.1038/ng.501

This protocol activated TrkB, AKT, and ERK signaling in vivo

doi: 10.1007/s00774-015-0702-2 92 NabaiLKilaniRTAminuddinFLiYGhaharyA

Future studies are warranted to test whether an inadequate mitochondrial quality control mechanism is responsible for mitochondrial dysfunction in adipocytes and adipose tissue inflammation